Philip R Kym Selected Research

acetamide

3/2005

Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.

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Philip R Kym Research Topics

Disease

12	Pain (Aches) 01/2022 - 05/2008
6	Obesity 02/2008 - 04/2003
4	Weight Loss (Weight Reduction) 02/2008 - 03/2005
3	Hyperthermia 04/2015 - 03/2009
2	Inflammation (Inflammations) 10/2023 - 03/2012
2	Neoplasms (Cancer) 10/2023 - 09/2013
2	Parkinson Disease (Parkinson's Disease) 09/2021 - 01/2021
2	Cystic Fibrosis (Mucoviscidosis) 09/2021 - 01/2020
2	Hypothermia 04/2015 - 03/2014
2	Bone Neoplasms (Bone Cancer) 08/2012 - 03/2009
2	Hyperalgesia 03/2012 - 05/2011
2	Type 2 Diabetes Mellitus (MODY) 07/2005 - 08/2004
1	Neuralgia (Stump Neuralgia) 01/2016
1	Intractable Pain 09/2013
1	Diabetic Neuropathies (Diabetic Neuropathy) 09/2013
1	Hyperlipidemias (Hyperlipidemia) 07/2010
1	Hypertriglyceridemia 08/2009
1	Neurogenic Inflammation 05/2008
1	Metabolic Diseases (Metabolic Disease) 02/2008
1	Insulin Resistance 06/2007
1	Mood Disorders (Mood Disorder) 07/2006
1	Adrenal Insufficiency (Adrenal Gland Hypofunction) 08/2004
1	Overactive Urinary Bladder (Overactive Bladder) 06/2004
1	Body Weight (Weight, Body) 04/2003
1	Edema (Dropsy) 03/2003
1	Immune System Diseases (Immune Disorders) 01/2003

Drug/Important Bio-Agent (IBA)

5	melanin-concentrating hormone receptorIBA 01/2007 - 04/2003
4	LigandsIBA 04/2015 - 04/2003
4	Analgesics (Analgesic Drugs)IBA 05/2011 - 03/2009
3	AcidsIBA 09/2014 - 03/2009
3	TRPV1 receptorIBA 03/2012 - 08/2010
3	LipidsIBA 08/2009 - 02/2008
3	GlucocorticoidsIBA 07/2005 - 01/2003
2	GLPG2222IBA 09/2021 - 01/2020
2	Capsaicin (Zostrix)FDA Link 09/2013 - 03/2009
2	A-889425IBA 03/2012 - 01/2011
2	Triglycerides (Triacylglycerol)IBA 08/2009 - 02/2008
2	melanin-concentrating hormone (melanin concentrating hormone)IBA 07/2006 - 04/2003
2	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 07/2005 - 08/2004
2	Glucose (Dextrose)FDA LinkGeneric 07/2005 - 08/2004
2	Prednisolone (Predate)FDA LinkGeneric 03/2003 - 01/2003
1	Immune Checkpoint InhibitorsIBA 10/2023
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 10/2023
1	EnzymesIBA 10/2023
1	Protein Tyrosine PhosphatasesIBA 10/2023
1	Voltage-Gated Sodium ChannelsIBA 01/2022
1	Sodium Channels (Sodium Channel)IBA 01/2022
1	Protein Isoforms (Isoforms)IBA 01/2022
1	Levodopa (L Dopa)FDA LinkGeneric 01/2021
1	ProdrugsIBA 01/2021
1	Carbidopa (Lodosyn)FDA LinkGeneric 01/2021
1	Phosphates (Orthophosphate)IBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2020
1	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2020
1	Reserpine (Serpasil)FDA Link 01/2016
1	AMG2850IBA 03/2014
1	resiniferatoxinIBA 09/2013
1	Freund's AdjuvantIBA 03/2012
1	A 967079IBA 05/2011
1	TRPA1 Cation ChannelIBA 05/2011
1	allyl isothiocyanateIBA 05/2011
1	A-995662IBA 08/2010
1	Glutamic Acid (Glutamate)FDA Link 08/2010
1	Insulin (Novolin)FDA Link 07/2010
1	Acyl Coenzyme A (Acyl CoA)IBA 07/2010
1	Diacylglycerol O-AcyltransferaseIBA 07/2010
1	OxazolesIBA 07/2010
1	(IR,2R)- 2- (4'- (3- phenyl- ureido)- biphenyl- 4- carbonyl)cyclopentanecarboxylic acidIBA 08/2009
1	HDL CholesterolIBA 08/2009
1	ABT 102IBA 03/2009
1	Ligand-Gated Ion ChannelsIBA 03/2009
1	CationsIBA 05/2008
1	ChylomicronsIBA 02/2008
1	LeptinIBA 06/2007
1	(3b,5b,7a,12a)- 7,12- dihydroxy- 3- (2- ((4- ((11b,17b)- 17- hydroxy- 3- oxo- 17- prop- 1- ynylestra- 4,9- dien- 11- yl) phenyl)(methyl)amino)ethoxy)cholan- 24- oic acidIBA 07/2005
1	Blood Glucose (Blood Sugar)IBA 07/2005
1	IndazolesIBA 06/2005
1	Urea (Carbamide)FDA LinkGeneric 06/2005
1	acetamideIBA 03/2005
1	Adenosine Triphosphate (ATP)IBA 06/2004
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 04/2003
1	NeuropeptidesIBA 04/2003
1	CarrageenanIBA 03/2003
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2003
1	SteroidsIBA 01/2003

Therapy/Procedure

2	Therapeutics 10/2023 - 09/2013
2	Injections 01/2017 - 09/2013
2	Analgesia 09/2013 - 08/2012
1	Immunotherapy 10/2023
1	Oral Administration 02/2007